MRPL41

Across TCGA pan-cancer cohorts, MRPL41 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MRPL41 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher MRPL41 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL41 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PAAD show a favorable association.

UCS, ACC, and KIRC are the cancer types where MRPL41 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	All	0.252	0.611	<.001	120	view →
ACC	DFS	Median	All	0.241	0.649	<.001	102	view →
KIRC	DFS	Tertile	All	0.829	0.924	<.001	84	view →
UCEC	DFS	Tertile	All	0.871	0.628	<.001	64	view →
UVM	OS	Quartile	All	0.388	0.958	.001	61	view →
HNSC	DFS	Tertile	All	0.271	0.448	.010	28	view →
LAML	DFS	Tertile	All	0.420	0.616	.026	18	view →
LGG	DFS	Tertile	All	0.353	0.528	.001	18	view →
PAAD	DFS	Quartile	All	0.391	0.146	.012	16	view →
PRAD	DFS	Tertile	All	0.752	0.916	<.001	16	view →
READ	OS	Tertile	IV	0.516	0.924	.013	11	view →
KICH	OS	Median	III,IV	0.792	1.000	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MRPL41–UCS (DFS)

Open the UCS breakdown →