MRPL41

Across TCGA pan-cancer cohorts, MRPL41 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MRPL41’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MRPL41 RNA is repressed in tumor relative to normal tissue. In most cancer types MRPL41 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC, HNSC, and BRCA are the cancer types where MRPL41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.799	<.001	6	view →
HNSC	Male	III,IV	+0.784	.006	6	view →
BRCA	All	All	+0.310	.002	6	view →
BLCA	All	III,IV	+0.412	.026	5	view →
UCEC	All	All	+0.601	.005	4	view →
LIHC	Female	All	+0.705	.001	3	view →
LUAD	Female	II,III,IV	+0.416	.010	3	view →
STAD	All	All	+0.410	.005	3	view →
ESCA	Male	All	+0.668	.005	2	view →
PRAD	All	All	+0.556	<.001	2	view →
COAD	Female	II,III,IV	+0.519	.030	2	view →
LUSC	All	II,III,IV	+0.410	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MRPL41–KIRC

Open the KIRC breakdown →