MRPL39

Across TCGA patient cohorts, MRPL39 mutation is significantly associated with the RNA expression of many other genes, with 2,510 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL39-associated genes across cancer lineages are RNU6-794P, NCOA4P1, and LINC01923. Each is linked with MRPL39 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL39-to-partner and partner-to-MRPL39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-794P grouped by MRPL39-low versus MRPL39-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL39→partner) and Y-score (partner→MRPL39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-794P →	+0.451	+6.219	<.001	<.001	3	2
UCEC	NCOA4P1 →	+0.071	+1.917	<.001	.006	3	2
SKCM	LINC01923 →	+0.026	+4.913	<.001	.002	3	2
COAD	RN7SKP39 →	+0.184	+5.122	.002	.004	3	2
SKCM	RNU6-1151P →	+0.401	+5.624	<.001	.002	3	2
SKCM	MIR1302-5 →	+0.194	+5.199	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,510 associations by consensus.

RNU6-794P by MRPL39 expression — SKCM

Explore this box plot interactively →