MRPL39

Across TCGA pan-cancer cohorts, MRPL39 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MRPL39 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MRPL39 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL39 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PRAD show a favorable association.

UVM, LUAD, and SCLC are the cancer types where MRPL39 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.287	0.716	.001	91	view →
LUAD	DFS	Quartile	III,IV	0.517	0.873	.002	47	view →
SCLC	DFS	Median	All	0.535	0.959	.001	34	view →
LGG	OS	Tertile	All	0.382	0.572	<.001	32	view →
ACC	DFS	Quartile	All	0.312	0.764	.005	20	view →
CHOL	DFS	Median	II,III,IV	0.107	0.546	.008	20	view →
KIRC	OS	Median	All	0.703	0.557	.002	20	view →
CESC	DFS	Quartile	IV	0.281	0.765	.013	18	view →
PRAD	DFS	Median	All	0.930	0.841	.001	18	view →
PAAD	OS	Tertile	All	0.249	0.531	.001	15	view →
MESO	DFS	Quartile	IV	0.477	0.815	.013	15	view →
SARC	OS	Quartile	All	0.381	0.762	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MRPL39–UVM (DFS)

Open the UVM breakdown →