MRPL39

Across TCGA pan-cancer cohorts, MRPL39 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MRPL39’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MRPL39 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPL39 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

BLCA, KICH, and THCA are the cancer types where MRPL39 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL39 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+0.557	<.001	10	view →
KICH	Female	All	−0.940	<.001	7	view →
THCA	All	All	−0.224	<.001	7	view →
UCEC	All	All	+0.473	.002	6	view →
PAAD	Female	All	−0.474	.028	4	view →
LUSC	All	All	+0.388	<.001	4	view →
LUAD	All	All	+0.235	<.001	4	view →
BRCA	All	All	+0.117	.021	2	view →
LIHC	Female	III,IV	+0.315	.016	1	view →
KIRP	All	All	−0.225	.038	1	view →
KIRC	Female	All	+0.220	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MRPL39–BLCA

Open the BLCA breakdown →