MRPL37

Across TCGA patient cohorts, MRPL37 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL37-associated genes across cancer lineages are PKC-delta_pS664, STAT3_pY705, and 14-3-3_epsilon. Each is linked with MRPL37 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL37-to-partner and partner-to-MRPL37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by MRPL37-low versus MRPL37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL37→partner) and Y-score (partner→MRPL37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.105	-2.449	.030	.019	3	2
UCEC	STAT3_pY705 →	-0.365	-1.906	<.001	.016	3	2
BLCA	14-3-3_epsilon →	+0.134	+2.824	.010	.036	3	1
UCEC	EGFR_pY1068 →	-0.278	-1.906	.005	.016	3	1
UCEC	FASN →	+0.499	+1.906	.001	.016	3	1
UCEC	GATA6 →	-0.168	-1.693	.010	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PKC-delta_pS664 by MRPL37 expression — UCEC

Explore this box plot interactively →