MRPL22

Across TCGA patient cohorts, MRPL22 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL22-associated genes across cancer lineages are RNU6-967P, RNU6-1034P, and MIR575. Each is linked with MRPL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL22-to-partner and partner-to-MRPL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-967P grouped by MRPL22-low versus MRPL22-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL22→partner) and Y-score (partner→MRPL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-967P →	+1.741	+5.625	<.001	.004	3	1
LUSC	RNU6-1034P →	+0.436	+5.337	<.001	.006	3	1
LUSC	MIR575 →	+0.582	+5.474	<.001	.005	3	1
LUSC	MIR610 →	+0.446	+4.984	<.001	.009	3	1
LUSC	MTATP6P31 →	+0.079	+5.404	<.001	.005	3	1
LUSC	RNU6-613P →	+0.579	+4.984	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

RNU6-967P by MRPL22 expression — LUSC

Explore this box plot interactively →