MRPL2

Across TCGA patient cohorts, MRPL2 mutation is significantly associated with the RNA expression of many other genes, with 574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL2-associated genes across cancer lineages are MIR1245A, RNU1-143P, and CIDECP1. Each is linked with MRPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL2-to-partner and partner-to-MRPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1245A grouped by MRPL2-low versus MRPL2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL2→partner) and Y-score (partner→MRPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR1245A →	+0.517	+3.653	<.001	.009	3	2
BRCA	RNU1-143P →	+0.339	+5.639	<.001	.002	3	2
UCEC	CIDECP1 →	+0.373	+3.544	<.001	.002	3	2
SKCM	RNU6-657P →	+0.246	+5.225	<.001	.001	3	2
COAD	ATP5PBP4 →	+0.070	+5.824	<.001	.001	3	2
COAD	WBP1LP1 →	+0.121	+4.271	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 574 associations by consensus.

MIR1245A by MRPL2 expression — CESC

Explore this box plot interactively →