MRPL2

Across TCGA pan-cancer cohorts, MRPL2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MRPL2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MRPL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPL2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, HNSC, and KICH are the cancer types where MRPL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.753	<.001	11	view →
HNSC	Male	III,IV	+0.591	<.001	9	view →
KICH	Female	II,III,IV	−1.178	<.001	8	view →
LUSC	Female	II,III,IV	+0.848	<.001	8	view →
LIHC	Male	II,III,IV	+0.811	<.001	8	view →
STAD	All	II,III,IV	+0.727	<.001	8	view →
LUAD	All	III,IV	+0.535	<.001	8	view →
BLCA	All	All	+0.457	.001	8	view →
CHOL	Female	All	+0.796	<.001	5	view →
KIRP	Female	II,III,IV	+0.622	.012	4	view →
THCA	All	III,IV	−0.281	.015	3	view →
ESCA	All	All	+0.855	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MRPL2–COAD

Open the COAD breakdown →