MRPL2

Across TCGA pan-cancer cohorts, MRPL2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MRPL2 data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MRPL2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and THYM show a favorable association.

ACC, KICH, and SCLC are the cancer types where MRPL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.280	0.639	<.001	55	view →
KICH	DFS	Tertile	II,III,IV	0.407	1.000	.001	54	view →
SCLC	OS	Quartile	All	0.905	0.612	.004	36	view →
BLCA	OS	Median	III,IV	0.610	0.752	.004	28	view →
LGG	OS	Quartile	All	0.721	0.859	.002	25	view →
UCS	DFS	Tertile	IV	0.250	0.849	.010	24	view →
SARC	OS	Quartile	All	0.614	0.805	.003	21	view →
THYM	DFS	Tertile	All	1.000	0.737	.007	18	view →
LAML	DFS	Quartile	All	0.326	0.677	.009	18	view →
LUAD	OS	Median	III,IV	0.515	0.793	.002	17	view →
UCEC	OS	Median	All	0.833	0.913	.001	16	view →
PRAD	DFS	Median	All	0.704	0.878	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MRPL2–ACC (DFS)

Open the ACC breakdown →