MRPL2

Across TCGA cell cohorts, MRPL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,540 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRPL2-associated GO terms across cancer lineages are Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Protein peptidyl-prolyl isomerization, and DNA replication initiation. Each is linked with MRPL2 in more than 12 cancer types. Because this analysis shows association rather than direction, both MRPL2-to-partner and partner-to-MRPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by MRPL2-low versus MRPL2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL2→partner) and Y-score (partner→MRPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.123	+0.559	.004	.002	3	13
PANCREAS	Protein peptidyl-prolyl isomerization →	+0.119	+0.692	.002	.002	3	12
LARGE_INTESTINE	DNA replication initiation →	+0.131	+0.553	<.001	<.001	3	12
OESOPHAGUS	Purine nucleobase transport →	+0.144	+0.736	.002	<.001	3	12
BONE	Maturation of LSU-rRNA →	+0.147	+0.649	.002	<.001	3	11
BONE	rRNA metabolic process →	+0.126	+0.555	.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,540 associations by consensus.

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by MRPL2 expression — BONE

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