MRPL2

Across TCGA cell cohorts, MRPL2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRPL2-associated genes across cancer lineages are C1QL2, OR2A5, and KRTAP4-7. Each is linked with MRPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL2-to-partner and partner-to-MRPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QL2 grouped by MRPL2-low versus MRPL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL2→partner) and Y-score (partner→MRPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR2A5 →	+0.028	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP4-7 →	+0.056	+6.569	<.001	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C1QL2 by MRPL2 expression — BLOOD_Leukemia

Explore this box plot interactively →