MRPL2

Across TCGA cell cohorts, MRPL2 mutation is significantly associated with the mutation status of many other genes, with 1,542 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRPL2-associated genes across cancer lineages are OPRL1, TRAF7, and OR56B4. Each is linked with MRPL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRPL2-to-partner and partner-to-MRPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRL1 grouped by MRPL2-low versus MRPL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL2→partner) and Y-score (partner→MRPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OPRL1 →	+4.560	+4.870	<.001	<.001	1	3
BLOOD_Leukemia	TRAF7 →	+3.560	+4.247	.002	.002	1	3
BLOOD_Leukemia	OR56B4 →	+4.560	+4.309	.007	.007	1	3
BLOOD_Leukemia	RANBP9 →	+3.823	+4.430	.001	.001	1	2
LARGE_INTESTINE	POLDIP3 →	+4.523	+5.087	.006	.006	1	2
BLOOD_Leukemia	TAB1 →	+6.145	+5.479	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,542 associations by consensus.

OPRL1 by MRPL2 expression — BLOOD_Leukemia

Explore this box plot interactively →