MRPL15

Across TCGA patient cohorts, MRPL15 mutation is significantly associated with the RNA expression of many other genes, with 236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL15-associated genes across cancer lineages are VN1R4, DRD5P2, and RNU6-525P. Each is linked with MRPL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL15-to-partner and partner-to-MRPL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R4 grouped by MRPL15-low versus MRPL15-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL15→partner) and Y-score (partner→MRPL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VN1R4 →	+0.035	+5.505	<.001	.002	3	2
BRCA	DRD5P2 →	+0.033	+4.610	<.001	.008	3	1
BRCA	RNU6-525P →	+0.430	+5.215	<.001	.003	3	1
BRCA	LYARP1 →	+0.027	+4.721	.003	.007	3	1
BRCA	NMD3P2 →	+0.131	+5.026	<.001	.002	3	1
BRCA	RN7SL332P →	+0.240	+6.125	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 236 associations by consensus.

VN1R4 by MRPL15 expression — BRCA

Explore this box plot interactively →