MROH9

Across TCGA cell cohorts, MROH9 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MROH9-associated genes across cancer lineages are DBX2, LINGO4, and NPY2R. Each is linked with MROH9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH9-to-partner and partner-to-MROH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX2 grouped by MROH9-low versus MROH9-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH9→partner) and Y-score (partner→MROH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	2
BLOOD_Leukemia	LINGO4 →	+0.175	+4.481	.002	<.001	3	2
LUNG_NSCLC_LUAD	NPY2R →	+0.018	+2.364	.008	.006	3	2
LARGE_INTESTINE	OR2C1 →	+0.082	+3.578	.009	.006	3	2
URINARY_TRACT	CHIA →	+1.476	+5.087	<.001	.004	3	1
URINARY_TRACT	C14orf180 →	+0.389	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

DBX2 by MROH9 expression — PANCREAS

Explore this box plot interactively →