Across TCGA patient cohorts, MROH2A mutation is significantly associated with the RNA expression of many other genes, with 779 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH2A-associated genes across cancer lineages are RNU1-17P, ALDOA, and CENPU. Each is linked with MROH2A in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH2A-to-partner and partner-to-MROH2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH2A→partner) and Y-score (partner→MROH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-17P →	+0.280	+5.103	<.001	.008	3	2
UCEC	ALDOA →	+0.558	+3.483	.006	.002	3	1
UCEC	CENPU →	+0.838	+3.732	.002	<.001	3	1
UCEC	SLC25A28 →	+0.385	+3.353	.003	.005	3	1
UCEC	SEC13 →	+0.520	+3.491	<.001	.002	3	1
UCEC	APOA2 →	+0.758	+2.771	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 779 associations by consensus.

Exploration

MROH2A survival (RNA) · tumor vs normal (RNA) · all MROH2A data types