Across TCGA patient cohorts, MROH2A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MROH2A-associated genes across cancer lineages are S6_pS240_S244, SETD2, and Tuberin. Each is linked with MROH2A in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH2A-to-partner and partner-to-MROH2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH2A→partner) and Y-score (partner→MROH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.658	+2.820	.003	.035	3	1
UCEC	SETD2 →	-0.242	-3.169	.043	.020	3	1
UCEC	Tuberin →	+0.546	+3.179	<.001	.010	3	1
UCEC	VHL →	-1.485	-3.169	<.001	.019	3	1
UCEC	Chk1 →	-0.194	-2.999	.032	.035	3	1
UCEC	C-Raf →	+0.212	+3.169	.006	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

MROH2A survival (RNA) · tumor vs normal (RNA) · all MROH2A data types