Across TCGA cell cohorts, MROH2A mutation is significantly associated with the RNA expression of many other genes, with 285 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MROH2A-associated genes across cancer lineages are ZP4, SLC5A8, and OR2A42. Each is linked with MROH2A in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH2A-to-partner and partner-to-MROH2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH2A→partner) and Y-score (partner→MROH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZP4 →	+0.016	+5.539	<.001	.003	3	2
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	2
SOFT_TISSUE	OR2A42 →	+0.055	+3.247	.001	.003	3	1
OESOPHAGUS	SCYGR2 →	+0.072	+2.857	<.001	.007	3	1
OESOPHAGUS	COL19A1 →	+0.062	+3.502	<.001	.007	3	1
URINARY_TRACT	HTR3B →	+0.027	+3.584	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 285 associations by consensus.

Exploration

MROH2A survival (RNA) · tumor vs normal (RNA) · all MROH2A data types