MRGPRF

Across TCGA cell cohorts, MRGPRF mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MRGPRF-associated genes across cancer lineages are ACTRT1, WFDC8, and FAM71B. Each is linked with MRGPRF in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRF-to-partner and partner-to-MRGPRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTRT1 grouped by MRGPRF-low versus MRGPRF-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRF→partner) and Y-score (partner→MRGPRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ACTRT1 →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	WFDC8 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	FAM71B →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	LCE1D →	+0.206	+4.906	<.001	.006	3	1
OESOPHAGUS	KRT28 →	+0.016	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	IL17F →	+0.085	+3.977	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ACTRT1 by MRGPRF expression — OESOPHAGUS

Explore this box plot interactively →