MRGPRF

Across TCGA pan-cancer cohorts, MRGPRF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MRGPRF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MRGPRF RNA is repressed in tumor relative to normal tissue. In most cancer types MRGPRF is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and KIRP are the cancer types where MRGPRF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRGPRF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.303	<.001	12	view →
BLCA	Male	III,IV	−4.385	<.001	11	view →
KIRP	Female	All	−2.763	<.001	9	view →
COAD	Male	All	−1.860	<.001	9	view →
THCA	All	II,III,IV	−1.155	<.001	9	view →
UCEC	All	III,IV	−5.084	<.001	8	view →
KICH	Female	All	−3.512	<.001	8	view →
LUSC	All	All	−1.113	<.001	7	view →
BRCA	All	II,III,IV	−1.958	<.001	6	view →
LUAD	Female	All	−0.952	<.001	6	view →
STAD	All	All	−1.456	.005	4	view →
READ	All	All	−2.614	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MRGPRF–KIRC

Open the KIRC breakdown →