MRC1

Across TCGA patient cohorts, MRC1 mutation is significantly associated with the RNA expression of many other genes, with 5,345 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRC1-associated genes across cancer lineages are PPM1G, COASY, and USP39. Each is linked with MRC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MRC1-to-partner and partner-to-MRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPM1G grouped by MRC1-low versus MRC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRC1→partner) and Y-score (partner→MRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PPM1G →	+0.392	+3.399	<.001	.004	3	6
UCEC	COASY →	+0.482	+1.713	<.001	<.001	3	6
STAD	USP39 →	+0.459	+3.355	.001	.005	3	5
STAD	TRAIP →	+0.696	+3.355	.001	.005	3	5
SKCM	CEP85 →	+0.480	+1.531	<.001	.003	3	5
COAD	AURKB →	+0.645	+3.348	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,345 associations by consensus.

PPM1G by MRC1 expression — COAD

Explore this box plot interactively →