MRAS

Across TCGA patient cohorts, MRAS protein abundance is significantly associated with the RNA expression of many other genes, with 12,310 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MRAS-associated genes across cancer lineages are CDH5, MAN1C1, and PMP22. Each is linked with MRAS in more than 6 cancer types. Because this analysis shows association rather than direction, both MRAS-to-partner and partner-to-MRAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MRAS versus CDH5 in OV, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRAS→partner) and Y-score (partner→MRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDH5 →	+1.085	+0.577	<.001	<.001	3	7
HNSC	MAN1C1 →	+0.695	+0.536	.008	<.001	3	7
OV	PMP22 →	+0.905	+0.596	<.001	<.001	3	6
OV	ARHGEF6 →	+1.066	+0.540	<.001	.002	3	6
BRCA	TGFBR2 →	+0.930	+0.575	<.001	<.001	3	6
OV	MAGI2-AS3 →	+0.790	+0.489	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,310 associations by consensus.

MRAS vs CDH5 — OV

Explore this scatter interactively →