MRAS

Across TCGA pan-cancer cohorts, MRAS RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MRAS data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MRAS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MRAS expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UCEC, KIRC, and UCS are the cancer types where MRAS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.892	0.958	<.001	60	view →
KIRC	DFS	Tertile	III,IV	0.648	0.305	<.001	53	view →
UCS	OS	Median	III,IV	0.793	0.352	<.001	46	view →
SKCM	OS	Median	All	0.402	0.268	.001	45	view →
MESO	DFS	Tertile	All	0.131	0.588	.006	30	view →
BRCA	DFS	Quartile	IV	0.421	0.873	.002	28	view →
LUAD	OS	Quartile	II,III,IV	0.795	0.622	.005	26	view →
LUSC	DFS	Median	II,III,IV	0.311	0.495	.003	23	view →
ACC	DFS	Quartile	All	0.211	0.701	.004	21	view →
KIRP	DFS	Median	II,III,IV	0.948	0.502	.007	18	view →
SCLC	DFS	Tertile	II,III,IV	0.910	0.152	.006	15	view →
THCA	DFS	Median	IV	1.000	0.591	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MRAS–UCEC (OS)

Open the UCEC breakdown →