MPHOSPH6

Across TCGA patient cohorts, MPHOSPH6 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MPHOSPH6-associated genes across cancer lineages are RNU6-1059P, MIR4650-2, and SDR42E1P1. Each is linked with MPHOSPH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPHOSPH6-to-partner and partner-to-MPHOSPH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1059P grouped by MPHOSPH6-low versus MPHOSPH6-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH6→partner) and Y-score (partner→MPHOSPH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-1059P →	+0.328	+8.471	<.001	.005	3	2
LUSC	MIR4650-2 →	+0.474	+6.309	<.001	.001	3	2
BRCA	SDR42E1P1 →	+0.079	+9.057	<.001	.003	3	1
UCEC	RN7SL248P →	+0.154	+4.722	<.001	.004	3	1
BLCA	SNRPBP1 →	+0.228	+4.363	<.001	.007	3	1
BLCA	ADIPOR1P1 →	+0.048	+4.971	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

RNU6-1059P by MPHOSPH6 expression — BRCA

Explore this box plot interactively →