MPHOSPH6

Across TCGA pan-cancer cohorts, MPHOSPH6 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MPHOSPH6 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher MPHOSPH6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MPHOSPH6 expression acts as an unfavorable survival marker, although some lineages such as OV and READ show a favorable association.

LIHC, HNSC, and OV are the cancer types where MPHOSPH6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.604	0.762	<.001	91	view →
HNSC	DFS	Tertile	All	0.665	0.784	.001	60	view →
OV	OS	Median	All	0.384	0.264	.001	52	view →
SARC	DFS	Tertile	All	0.524	0.685	.008	27	view →
LUAD	DFS	Median	II,III,IV	0.184	0.330	.008	26	view →
ACC	OS	Median	III,IV	0.306	0.792	<.001	21	view →
READ	OS	Median	II,III,IV	0.719	0.528	.022	18	view →
UCS	OS	Tertile	III,IV	0.604	0.171	.013	18	view →
THYM	OS	Median	All	0.956	0.601	.011	14	view →
BLCA	OS	Quartile	IV	0.274	0.643	.012	14	view →
CESC	DFS	Quartile	III,IV	0.271	0.775	.014	8	view →
LGG	OS	Quartile	All	0.851	0.948	.017	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MPHOSPH6–LIHC (OS)

Open the LIHC breakdown →