MON1B

Across TCGA cell cohorts, MON1B mutation is significantly associated with the RNA expression of many other genes, with 189 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MON1B-associated genes across cancer lineages are LRRC72, AKAIN1, and TNFRSF10A. Each is linked with MON1B in more than 1 cancer types. Because this analysis shows association rather than direction, both MON1B-to-partner and partner-to-MON1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC72 grouped by MON1B-low versus MON1B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MON1B→partner) and Y-score (partner→MON1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LRRC72 →	+0.327	+5.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	AKAIN1 →	+0.099	+4.371	<.001	.005	3	1
LARGE_INTESTINE	TNFRSF10A →	+0.799	+3.451	.007	.002	3	1
LARGE_INTESTINE	KDELR1 →	+0.536	+3.169	.003	.009	3	1
LARGE_INTESTINE	RAB3A →	+0.818	+3.451	.004	.002	3	1
LARGE_INTESTINE	MINPP1 →	+0.595	+3.451	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 189 associations by consensus.

LRRC72 by MON1B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →