MON1B

Across TCGA pan-cancer cohorts, MON1B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MON1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MON1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MON1B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, THCA, and HNSC are the cancer types where MON1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MON1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	+1.154	<.001	11	view →
THCA	Male	III,IV	−0.929	<.001	11	view →
HNSC	All	III,IV	+0.684	<.001	10	view →
LIHC	All	II,III,IV	+0.705	<.001	8	view →
STAD	Male	II,III,IV	+0.890	<.001	7	view →
BLCA	All	All	+0.470	.003	6	view →
CHOL	Male	All	+1.738	<.001	5	view →
KICH	All	All	−0.417	.004	5	view →
LUSC	Male	All	−0.270	.007	4	view →
KIRC	All	All	+0.188	.005	4	view →
PRAD	All	All	+1.308	<.001	2	view →
BRCA	Female	All	−0.159	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MON1B–KIRP

Open the KIRP breakdown →