MON1B

Across TCGA pan-cancer cohorts, MON1B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MON1B data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher MON1B RNA is associated with better overall survival. In most high-consensus cancer types, elevated MON1B expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

SCLC, HNSC, and KIRC are the cancer types where MON1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	III,IV	0.813	0.384	<.001	78	view →
HNSC	DFS	Tertile	IV	0.789	0.543	<.001	45	view →
KIRC	OS	Median	All	0.707	0.556	.001	26	view →
LUAD	DFS	Median	All	0.738	0.841	.001	25	view →
BLCA	DFS	Median	All	0.195	0.499	.007	24	view →
MESO	OS	Tertile	II,III,IV	0.718	0.388	.001	24	view →
LUSC	DFS	Tertile	All	0.323	0.482	.008	22	view →
CESC	DFS	Quartile	II,III,IV	0.568	0.892	.003	18	view →
SARC	OS	Median	All	0.579	0.437	.004	17	view →
LIHC	DFS	Median	All	0.489	0.612	.008	17	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	12	view →
SKCM	DFS	Tertile	All	0.265	0.154	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MON1B–SCLC (OS)

Open the SCLC breakdown →