MOB3B

Across TCGA patient cohorts, MOB3B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB3B-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and GAPDH. Each is linked with MOB3B in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB3B-to-partner and partner-to-MOB3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MOB3B-low versus MOB3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB3B→partner) and Y-score (partner→MOB3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.260	-2.321	.039	.035	3	1
UCEC	FoxM1 →	+0.332	+2.321	.010	.035	3	1
UCEC	GAPDH →	+0.638	+2.321	.017	.035	3	1
UCEC	INPP4B →	-0.379	-3.446	.019	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.252	-2.308	.002	.036	3	1
UCEC	Myosin-IIa →	+0.236	+2.329	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by MOB3B expression — UCEC

Explore this box plot interactively →