MOB1A

Across TCGA patient cohorts, MOB1A mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB1A-associated genes across cancer lineages are OR51G1, RN7SKP221, and TRDD1. Each is linked with MOB1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB1A-to-partner and partner-to-MOB1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51G1 grouped by MOB1A-low versus MOB1A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB1A→partner) and Y-score (partner→MOB1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR51G1 →	+0.034	+7.731	<.001	.009	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1
BRCA	RNU6-65P →	+0.307	+8.055	<.001	.007	3	1
UCEC	NAE1 →	+0.655	+3.218	.007	.009	3	1
UCEC	DTYMK →	+0.666	+3.234	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

OR51G1 by MOB1A expression — BRCA

Explore this box plot interactively →