MOB1A

Across TCGA pan-cancer cohorts, MOB1A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MOB1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MOB1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MOB1A is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where MOB1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MOB1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.024	<.001	12	view →
BLCA	Female	All	+0.773	<.001	11	view →
LIHC	Female	II,III,IV	+0.853	<.001	9	view →
STAD	All	II,III,IV	+0.769	<.001	8	view →
KICH	Female	II,III,IV	−1.481	<.001	7	view →
LUSC	Male	All	+0.430	<.001	6	view →
BRCA	All	II,III,IV	+0.360	<.001	6	view →
CHOL	Male	All	+2.196	<.001	5	view →
ESCA	All	All	+1.025	.001	2	view →
PRAD	All	All	−0.283	.008	2	view →
LUAD	All	All	+0.153	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MOB1A–HNSC

Open the HNSC breakdown →