MOB1A

Across TCGA pan-cancer cohorts, MOB1A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MOB1A data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MOB1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MOB1A expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

ACC, SKCM, and LGG are the cancer types where MOB1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.263	0.639	<.001	86	view →
SKCM	OS	Tertile	All	0.365	0.233	<.001	81	view →
LGG	OS	Median	All	0.358	0.553	<.001	54	view →
LIHC	OS	Median	All	0.612	0.759	<.001	54	view →
KIRC	DFS	Median	All	0.725	0.493	.001	41	view →
MESO	OS	Median	III,IV	0.272	0.489	.003	35	view →
LUSC	OS	Quartile	All	0.782	0.529	.012	28	view →
PAAD	DFS	Tertile	All	0.395	0.560	.018	24	view →
KIRP	OS	Tertile	All	0.884	0.951	.018	22	view →
UVM	DFS	Quartile	III,IV	0.183	0.832	<.001	20	view →
HNSC	OS	Tertile	All	0.292	0.536	.002	20	view →
LUAD	DFS	Tertile	IV	0.670	0.120	.020	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MOB1A–ACC (DFS)

Open the ACC breakdown →