MNT

Across TCGA patient cohorts, MNT mutation is significantly associated with the RNA expression of many other genes, with 2,723 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MNT-associated genes across cancer lineages are NF1P4, PHBP15, and BNIP3P32. Each is linked with MNT in more than 1 cancer types. Because this analysis shows association rather than direction, both MNT-to-partner and partner-to-MNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P4 grouped by MNT-low versus MNT-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MNT→partner) and Y-score (partner→MNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	NF1P4 →	+0.414	+5.192	<.001	.001	3	2
LUSC	PHBP15 →	+0.064	+4.548	<.001	.009	3	2
LUSC	BNIP3P32 →	+0.152	+4.548	<.001	.009	3	2
CESC	RNA5SP432 →	+0.329	+5.539	<.001	.004	3	2
UCEC	RNA5SP410 →	+0.614	+2.151	<.001	<.001	3	2
SKCM	ELOAP1 →	+0.011	+5.485	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,723 associations by consensus.

NF1P4 by MNT expression — LUSC

Explore this box plot interactively →