MMS19

Across TCGA cell cohorts, MMS19 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MMS19-associated genes across cancer lineages are TAS2R39, ITGAD, and SPATA4. Each is linked with MMS19 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMS19-to-partner and partner-to-MMS19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R39 grouped by MMS19-low versus MMS19-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMS19→partner) and Y-score (partner→MMS19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAS2R39 →	+0.041	+3.339	.003	.006	3	2
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	2
BLOOD_Leukemia	SPATA4 →	+0.132	+3.784	<.001	.008	3	1
BLOOD_Leukemia	CLDN8 →	+0.009	+3.234	<.001	.008	3	1
BLOOD_Leukemia	CD1B →	+4.706	+3.619	<.001	.007	3	1
BLOOD_Leukemia	SPACA5 →	+0.160	+3.745	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TAS2R39 by MMS19 expression — BLOOD_Leukemia

Explore this box plot interactively →