MMS19

Across TCGA pan-cancer cohorts, MMS19 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MMS19 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MMS19 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MMS19 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

ACC, CESC, and LIHC are the cancer types where MMS19 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.168	0.718	<.001	126	view →
CESC	DFS	Quartile	All	0.710	0.871	.001	90	view →
LIHC	DFS	Median	All	0.455	0.626	<.001	83	view →
UVM	DFS	Tertile	All	0.253	0.696	<.001	74	view →
LGG	OS	Median	All	0.872	0.745	<.001	48	view →
BLCA	OS	Quartile	All	0.503	0.706	<.001	48	view →
UCS	OS	Median	IV	0.817	0.302	.002	42	view →
UCEC	DFS	Median	IV	0.634	0.266	.010	26	view →
OV	OS	Tertile	III,IV	0.790	0.882	.003	24	view →
SCLC	DFS	Tertile	II,III,IV	0.976	0.342	.006	18	view →
MESO	DFS	Tertile	IV	0.164	0.580	.015	15	view →
GBM	DFS	Tertile	All	0.465	0.210	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MMS19–ACC (DFS)

Open the ACC breakdown →