MMP8

Across TCGA cell cohorts, MMP8 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP8-associated genes across cancer lineages are HBM, IL2, and SSMEM1. Each is linked with MMP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP8-to-partner and partner-to-MMP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HBM grouped by MMP8-low versus MMP8-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP8→partner) and Y-score (partner→MMP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HBM →	+0.096	+5.781	<.001	.001	3	1
LARGE_INTESTINE	IL2 →	+0.048	+4.437	<.001	.004	3	1
LARGE_INTESTINE	SSMEM1 →	+0.027	+3.707	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

HBM by MMP8 expression — BREAST

Explore this box plot interactively →