MMP8

Across TCGA pan-cancer cohorts, MMP8 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MMP8 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MMP8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MMP8 expression acts as an unfavorable survival marker, although some lineages such as LIHC and THYM show a favorable association.

KIRC, ACC, and UVM are the cancer types where MMP8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.538	0.700	<.001	115	view →
ACC	OS	Tertile	All	0.726	0.935	<.001	94	view →
UVM	DFS	Tertile	All	0.071	0.746	<.001	45	view →
LUSC	OS	Median	III,IV	0.375	0.660	.004	43	view →
STAD	OS	Tertile	All	0.324	0.521	.015	40	view →
KICH	DFS	Tertile	All	0.701	0.959	.002	37	view →
CESC	OS	Tertile	All	0.417	0.725	<.001	36	view →
UCEC	OS	Tertile	All	0.899	0.947	.012	22	view →
PCPG	OS	Quartile	All	0.665	0.977	.001	17	view →
BLCA	DFS	Quartile	All	0.233	0.464	.011	17	view →
LGG	DFS	Median	All	0.677	0.774	.008	14	view →
TGCT	DFS	Quartile	All	0.480	0.798	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MMP8–KIRC (OS)

Open the KIRC breakdown →