MMP8

Across TCGA pan-cancer cohorts, MMP8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of MMP8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MMP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MMP8 is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where MMP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.446	<.001	11	view →
COAD	All	II,III,IV	+0.446	<.001	8	view →
LUAD	Female	II,III,IV	+0.701	<.001	7	view →
BLCA	All	All	+0.243	.036	3	view →
BRCA	All	II,III,IV	+0.137	.022	3	view →
STAD	Male	III,IV	+0.133	.011	3	view →
LIHC	Male	All	−0.034	.002	3	view →
LUSC	All	All	+0.472	.001	2	view →
UCEC	All	All	+0.070	.027	2	view →
THCA	All	All	+0.055	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

MMP8–HNSC

Open the HNSC breakdown →