MMP26

Across TCGA patient cohorts, MMP26 mutation is significantly associated with the RNA expression of many other genes, with 3,656 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP26-associated genes across cancer lineages are TRGJP2, STING1, and CDKN3. Each is linked with MMP26 in more than 3 cancer types. Because this analysis shows association rather than direction, both MMP26-to-partner and partner-to-MMP26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP2 grouped by MMP26-low versus MMP26-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP26→partner) and Y-score (partner→MMP26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TRGJP2 →	+0.711	+4.266	.002	.003	3	4
UCEC	STING1 →	-0.651	-2.407	.001	.003	3	3
UCEC	CDKN3 →	+0.853	+2.949	<.001	<.001	3	3
UCEC	OIP5 →	+0.885	+2.960	<.001	<.001	3	3
UCEC	NCAPH →	+0.676	+2.914	.001	.001	3	3
UCEC	PDCD2L →	+0.342	+3.606	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,656 associations by consensus.

TRGJP2 by MMP26 expression — BLCA

Explore this box plot interactively →