MMP26

Across TCGA pan-cancer cohorts, MMP26 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MMP26 data layer compared with 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MMP26 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MMP26 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

UCEC, KIRC, and CESC are the cancer types where MMP26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.956	0.870	.001	132	view →
KIRC	DFS	Median	All	0.466	0.709	<.001	108	view →
CESC	OS	Tertile	III,IV	0.487	0.791	.005	54	view →
SCLC	DFS	Median	II,III,IV	0.734	0.366	.001	51	view →
LIHC	OS	Tertile	All	0.183	0.580	<.001	45	view →
MESO	OS	Tertile	II,III,IV	0.329	0.580	.006	45	view →
LUSC	OS	Tertile	III,IV	0.054	0.768	<.001	18	view →
LAML	DFS	Tertile	All	0.138	0.598	<.001	18	view →
UCS	DFS	Quartile	II,III,IV	0.709	0.344	.020	16	view →
PCPG	DFS	Tertile	All	0.574	0.805	.013	15	view →
PRAD	DFS	Median	All	0.958	0.909	.029	10	view →
SKCM	DFS	Tertile	IV	0.016	0.541	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MMP26–UCEC (DFS)

Open the UCEC breakdown →