MMP26

Across TCGA pan-cancer cohorts, MMP26 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MMP26’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MMP26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MMP26 is over-expressed in tumor, although a few such as STAD and ESCA show the opposite, repressed pattern.

KICH, PRAD, and STAD are the cancer types where MMP26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMP26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	+0.999	.001	4	view →
PRAD	All	All	+1.692	<.001	2	view →
STAD	Male	IV	−0.130	.005	1	view →
ESCA	Female	All	−0.063	.016	1	view →
KIRC	All	II,III,IV	−0.019	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MMP26–KICH

Open the KICH breakdown →