MMP26

Across TCGA patient cohorts, MMP26 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP26-associated genes across cancer lineages are PDCD4, PKC-b-II_pS660, and Ku80. Each is linked with MMP26 in more than 2 cancer types. Because this analysis shows association rather than direction, both MMP26-to-partner and partner-to-MMP26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MMP26-low versus MMP26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP26→partner) and Y-score (partner→MMP26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.716	-2.000	<.001	.010	3	3
SKCM	PKC-b-II_pS660 →	-0.268	-1.999	.009	.002	3	3
UCEC	Ku80 →	+0.208	+2.009	.025	.017	3	2
SKCM	NDRG1_pT346 →	-0.503	-1.807	.030	.024	3	2
UCEC	PCNA →	+0.402	+3.169	<.001	<.001	3	2
SKCM	TFRC →	+0.519	+1.700	.008	.038	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

PDCD4 by MMP26 expression — UCEC

Explore this box plot interactively →