MMP20

Across TCGA patient cohorts, MMP20 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,949 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MMP20-associated GO terms across cancer lineages are Regulation of cellular response to transforming growth factor beta stimulus, Positive regulation of apoptotic signaling pathway, and Canonical NF-kappaB signal transduction. Each is linked with MMP20 in more than 15 cancer types. Because this analysis shows association rather than direction, both MMP20-to-partner and partner-to-MMP20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cellular response to transforming growth factor beta stimulus grouped by MMP20-low versus MMP20-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP20→partner) and Y-score (partner→MMP20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of cellular response to transforming growth factor beta stimulus →	+0.053	+0.129	<.001	.004	2	16
STAD	Positive regulation of apoptotic signaling pathway →	+0.080	+0.211	<.001	<.001	2	16
STAD	Canonical NF-kappaB signal transduction →	+0.075	+0.170	<.001	<.001	2	15
STAD	Positive regulation of establishment of protein localization to telomere →	+0.106	+0.248	<.001	<.001	3	14
STAD	Cytoplasmic translation →	+0.069	+0.206	<.001	<.001	3	14
ESCA	Regeneration →	+0.044	+0.336	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,949 associations by consensus.

Regulation of cellular response to transforming growth factor beta stimulus by MMP20 expression — STAD

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