MMP20

Across TCGA pan-cancer cohorts, MMP20 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MMP20 data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MMP20 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MMP20 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

ACC, KIRP, and CESC are the cancer types where MMP20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.227	0.681	<.001	117	view →
KIRP	DFS	Median	All	0.744	0.935	<.001	104	view →
CESC	OS	Tertile	IV	0.199	0.748	<.001	86	view →
LIHC	OS	Median	All	0.676	0.835	<.001	63	view →
LGG	DFS	Tertile	All	0.548	0.759	<.001	36	view →
PCPG	DFS	Tertile	All	0.463	0.898	<.001	36	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	27	view →
MESO	DFS	Tertile	All	0.132	0.511	.006	27	view →
LUAD	DFS	Quartile	II,III,IV	0.661	0.489	.012	23	view →
KIRC	DFS	Tertile	All	0.487	0.725	.004	21	view →
UCEC	OS	Quartile	All	0.400	0.778	.003	18	view →
SKCM	OS	Tertile	IV	0.264	0.778	.026	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MMP20–ACC (OS)

Open the ACC breakdown →