MMP20

Across TCGA pan-cancer cohorts, MMP20 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MMP20’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MMP20 RNA is repressed in tumor relative to normal tissue. In most cancer types MMP20 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

BRCA, COAD, and LUSC are the cancer types where MMP20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MMP20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.493	<.001	8	view →
COAD	All	II,III,IV	+0.273	<.001	6	view →
LUSC	Male	All	+0.150	<.001	6	view →
KIRP	All	All	−0.122	.001	6	view →
THCA	All	III,IV	+0.127	.019	4	view →
LUAD	All	All	+0.109	.002	4	view →
HNSC	Female	All	+0.215	.025	3	view →
KIRC	Female	All	−0.055	.013	2	view →
PAAD	Male	All	+0.050	.037	2	view →
BLCA	All	All	+0.018	.041	2	view →
STAD	All	All	+0.081	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MMP20–BRCA

Open the BRCA breakdown →