MMP20

Across TCGA patient cohorts, MMP20 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP20-associated genes across cancer lineages are GAPDH, MEK1, and mTOR_pS2448. Each is linked with MMP20 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP20-to-partner and partner-to-MMP20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by MMP20-low versus MMP20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP20→partner) and Y-score (partner→MMP20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.485	+3.169	.024	.018	3	2
UCEC	MEK1 →	+0.592	+3.906	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.218	-3.787	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.433	+2.341	.041	.019	3	2
UCEC	Rictor_pT1135 →	-0.123	-3.087	.002	<.001	3	2
UCEC	BRD4 →	+0.290	+3.169	.008	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

GAPDH by MMP20 expression — UCEC

Explore this box plot interactively →