MMP20

Across TCGA cell cohorts, MMP20 RNA expression is significantly associated with the go_rna of many other GO terms, with 856 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP20-associated GO terms across cancer lineages are Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, Negative regulation of reactive oxygen species biosynthetic process, and Regulation of bicellular tight junction assembly. Each is linked with MMP20 in more than 3 cancer types. Because this analysis shows association rather than direction, both MMP20-to-partner and partner-to-MMP20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis grouped by MMP20-low versus MMP20-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP20→partner) and Y-score (partner→MMP20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis →	+0.135	+0.049	.009	.007	3	4
LARGE_INTESTINE	Negative regulation of reactive oxygen species biosynthetic process →	+0.104	+0.235	.002	.005	3	4
LARGE_INTESTINE	Regulation of bicellular tight junction assembly →	+0.070	+0.241	<.001	.006	3	4
LARGE_INTESTINE	Lipoprotein metabolic process →	+0.043	+0.305	.001	.001	3	4
LARGE_INTESTINE	Regulation of dendritic spine development →	+0.055	+0.257	.001	.004	3	4
BLOOD_Lymphoma	Positive regulation of post-translational protein modification →	+0.034	+0.628	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 856 associations by consensus.

Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis by MMP20 expression — PANCREAS

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