MMP20

Across TCGA cell cohorts, MMP20 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MMP20-associated genes across cancer lineages are Oxaliplatin, IC-87114, and Rucaparib. Each is linked with MMP20 in more than 1 cancer types. Because this analysis shows association rather than direction, both MMP20-to-partner and partner-to-MMP20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxaliplatin grouped by MMP20-low versus MMP20-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP20→partner) and Y-score (partner→MMP20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Oxaliplatin →	+0.527	+2.871	.035	.021	3	1
LARGE_INTESTINE	IC-87114 →	+0.281	+2.652	.005	.045	3	1
LARGE_INTESTINE	Rucaparib →	+0.560	+2.932	<.001	.019	2	1
LARGE_INTESTINE	LMB_AB1 →	+0.298	+2.871	.035	.021	1	2
LARGE_INTESTINE	Teniposide →	+0.557	+2.871	.027	.021	2	1
LARGE_INTESTINE	Docetaxel →	+0.976	+2.807	.040	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Oxaliplatin by MMP20 expression — LARGE_INTESTINE

Explore this box plot interactively →