MMP16

Across TCGA patient cohorts, MMP16 mutation is significantly associated with the RNA expression of many other genes, with 6,662 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMP16-associated genes across cancer lineages are NDUFV1, PSMD12, and CD180. Each is linked with MMP16 in more than 3 cancer types. Because this analysis shows association rather than direction, both MMP16-to-partner and partner-to-MMP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFV1 grouped by MMP16-low versus MMP16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMP16→partner) and Y-score (partner→MMP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFV1 →	+0.255	+1.379	.005	<.001	3	4
UCEC	PSMD12 →	+0.298	+1.879	.001	<.001	3	4
LUAD	CD180 →	-0.474	-2.502	.004	.001	3	4
LUAD	CRTAC1 →	-1.003	-2.247	.004	.001	3	4
UCEC	COASY →	+0.397	+1.447	<.001	<.001	3	4
UCEC	KCTD9 →	+0.604	+1.695	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,662 associations by consensus.

NDUFV1 by MMP16 expression — UCEC

Explore this box plot interactively →