MMP16

Across TCGA pan-cancer cohorts, MMP16 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MMP16 data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MMP16 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MMP16 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

KIRP, UVM, and MESO are the cancer types where MMP16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.606	0.775	<.001	99	view →
UVM	DFS	Tertile	II,III,IV	0.250	0.730	<.001	98	view →
MESO	OS	Tertile	III,IV	0.261	0.559	<.001	87	view →
STAD	OS	Quartile	All	0.341	0.670	.001	60	view →
LIHC	OS	Quartile	All	0.450	0.750	<.001	41	view →
BLCA	DFS	Quartile	All	0.218	0.445	.003	36	view →
SARC	OS	Median	All	0.441	0.582	.003	26	view →
SKCM	OS	Median	III,IV	0.502	0.275	<.001	24	view →
COAD	DFS	Median	All	0.290	0.599	<.001	24	view →
LGG	OS	Median	All	0.943	0.827	<.001	22	view →
ESCA	OS	Tertile	All	1.000	0.489	.008	20	view →
UCEC	OS	Median	II,III,IV	0.913	0.791	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MMP16–KIRP (OS)

Open the KIRP breakdown →